About

Building upon broad interdisciplinary training, I have been pursuing research at the intersection of data science, informatics and biomedicine. My primary expertise lies in the fields of computational genomics, molecular modeling, and structural bioinformatics. On the methodological side, with a team of collaborators, we have developed a number of successful prediction methods for structural and functional studies of proteins and their complexes (Adamczak et al., 2004, 2005, 2011, 2016; Porollo and Meller, 2007, 2010; Phatak et al., 2011). I have also been active in the development and applications of methods for knowledge extraction from high dimensional genomic data (Sinha and Meller, 2008; Shinde et al., 2010; Huang et al., 2012, Pappas et al., 2017). As of January of 2020, these methods and web servers developed by our group, including Sppider, Cinteny and Polyview, have been used by over 100,000 users from many countries. I have also been involved in multiple high impact collaborative projects in the areas of basic and translational biomedical research. Examples of such interdisciplinary efforts include: sequencing, annotation and functional studies of human pathogens (Cushion et al, 2007; Liu et al., 2012, Walther et al., 2015, Mohanty et al., 2017), identification of markers associated with disease subtypes and clinical outcomes (Zhang et al., 2011; Biesiada et al., 2014, 2015, Chidambaran et al., 2017), modeling of signal transduction pathways in cancer, autoimmunity and brain disorders (Mikhaylova et al., 2012; Stratton et al., 2014, Dorsett et al., 2017), and developing inhibitors of critical protein-protein interactions or signaling events (Bosco et al., 2012; Evelyn et al., 2014, 2015, Liu et al., 2018). To date, I have published over 100 peer-reviewed contributions, with the ISI Web of Science h-index of >35. I served as PI, co-PI or co-Investigator on multiple NIH-funded and other grants, and I have a considerable experience in coordinating large-scale multidisciplinary projects. See professional profiles at http://scholar.google.com/citations?user=vQguoK4AAAAJ&hl=en and http://www.researcherid.com/rid/A-1971-2011 . In addition to research related activities, I have been broadly involved in quantitative and computational training efforts within the University of Cincinnati Colleges of Medicine and Engineering and Applied Sciences. I currently serve as the Director of the Division of Biostatistics and Bioinformatics, Director of the PhD Program in Biomedical Informatics, and co-director of the Biomedical Informatics Graduate Certificate Program.

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